A genomic perspective of the aging human and mouse lung with a focus on immune response and cellular senescence

Abstract Background The aging lung is a complex process and influenced by various stressors, especially airborne pathogens and xenobiotics.Additionally, a lifetime exposure to antigens results in structural and functional changes of the lung; yet an understanding of the cell type specific responses remains elusive.To gain insight into age-related c

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Machine learning-based identification of colorectal advanced adenoma using clinical and laboratory data: a phase I exploratory study in accordance with updated World Endoscopy Organization guidelines for noninvasive colorectal cancer screening tests

ObjectiveThe recent World Endoscopy Organization (WEO) guidelines now recognize precursor lesions of colorectal cancer (CRC) as legitimate screening targets.However, an optimal screening method for detecting advanced adenoma (AA), a significant precursor lesion, remains elusive.MethodsWe employed five machine learning methods, using clinical and la

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The monterey bay broadband ocean bottom seismic observatory

We report on the installation of a long-term buried ocean-floor broadband seismic station (MOBB) in Monterey Bay, California (USA), 40km off-shore, at a water depth of 1000 m.The station was installed in April 2002 using a ship and ROV, in a collaborative effort between the Monterey Bay Aquarium Research Institute (MBARI) and the Berkeley Seismolog

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